
Prof. Dr. Dirk Hoffmeister
Phone: +49 3641 532-1310 Email: dirk.hoffmeister@leibniz-hki.de Website: www.leibniz-hki.de/de/pharmazeutische-mikrobiologie.html
Projects
Current Projects
Biosynthesis of basidiomycete polyenes
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Elucidation of the biosynthesis of Sphingolipid inhibitors in Aspergillus fumigatus and Aspergillus niger
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Compounds from neglected bacteria and target analysis
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The biosynthesis, biochemistry and physiology of coenzyme 3PG-F420
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The biochemistry and physiology of the redox cofactor mycofactocin
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Former Projects
Investigation of secondary metabolites from insect-associated microbes and their contribution to insect homeostasis and defense
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Investigation of polyketide biosynthesis in agaricomycetes
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The role of Desulfitobacterium spp. in the global network of O-demethylation in soil
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Investigation of virulence-associated natural products from human-pathogenic Burkholderia spp.
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Publications
(2016) Unexpected Metabolic Versatility in a Combined Fungal Fomannoxin/Vibralactone Biosynthesis. J Nat Prod 79(5), 1407-1414. Details PubMed
(2015) Involutin Is an Fe3+ Reductant Secreted by the Ectomycorrhizal Fungus Paxillus involutus during Fenton-Based Decomposition of Organic Matter. Appl Environ Microbiol 81(24), 8427-8433. Details PubMed
(2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53(49), 13409-13413. Details PubMed
(2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete. J Nat Prod 77(12), 2658-2663. Details PubMed
(2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet Biol 53, 50-58. Details PubMed
(2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew Chem Int Ed Engl 52(5), 1590-1594. Details PubMed
(2012) Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A 109(14), 5458-5463. Details PubMed