On-line modification of processes in multimodular protein systems
To take a look into nature whenever humans needed medicine is a habit known since the beginning of mankind. One third of the FDA approved active substances is derived from natural products. Since the discovery of penicillin this field ofresearch has been introduced to scientist all over the world. Nowadays this field of research became even more important as the bacteria surrounding us in our world have become resistant against the common
antibiotics. To discover new compounds that can possibly be used as antibiotics it is not only necessary to take a look on the discovery of previous natural products but also to take a look on new and extraordinary systems in nature where bacteria or fungi produces compounds as secondary metabolites to protect themselves.
Three systems established in this lab are the interaction between Burkholderia rhizoxinica and Rhizopus microspores producing the compound rhizoxin. The interaction between the Janthinobacterium agaricidamnosum and Agaricus bisporus producing the compound Jagaricin. The secondary metabolites of Clostridiwn cellulolyticum, a bacterium extracted from soil.
These systems have in common that the biosynthesis of the compounds of interest here is based on PKS respectively NRPS gene clusters that perform interesting reactions building unique features within the natural products.
(2020) Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy. Proc Natl Acad Sci U S A ,
(2019) Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals a Novel Nonribosomal Peptide Backbone-Tailoring Strategy. Angew Chem Int Ed Engl 58, 13014-13018.
Start of PhD
February 1, 2017