Prof. Dr. Christian Hertweck
Investigation and application of bacterial biosynthetic pathways using chemical synthesis and molecular biological methods
Natural Products from underexplored bacteria
Compounds from neglected bacteria and target analysis
Investigation of new photochemical reactions
Investigations of Biosynthesis of Secondary Metabolites from Anaerobic Bacteria
Chemical ecology of pathogenic bacteria
Chemical and enzymatic modification for visualization of natural products in microbial interactions
Genome mining of Gram-positive bacteria for secondary metabolites
Molecular basis of bacterial-mushroom interactions
The genome of the endofungal bacterium Burkholderia rhizoxinica
Biochemical characterisation of bacterial terpene cyclases
Genomics-Driven Discovery of Secondary Metabolites from Burkholderia spp. that Interact with Fungi
Genomics-based search for natural products in neglected bacteria
On-line modification of processes in multimodular protein systems
Investigation of virulence-associated natural products from human-pathogenic Burkholderia spp.
(2015) Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte. J Nat Prod ,
(2015) Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announc 3(2),
(2015) Twofold polyketide branching by a stereoselective enzymatic Michael addition. Chem Commun (Camb) 51(48), 9872-9875.
(2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1),
(2015) Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417. Genome Announc 3(1),
(2015) Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Mol Microbiol 96(1), 148-162.
(2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nat Chem Biol 11(12), 949-951.
(2015) Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae. Chembiochem 16(3), 387-392.
(2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53(49), 13409-13413.
(2014) Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles. Angew Chem Int Ed Engl 53(43), 11645-11649.
(2014) Active invasion of bacteria into living fungal cells. Elife 3, e03007.
(2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264.
(2013) Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl 52(20), 5285-5289.
(2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942.
(2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109.
(2013) Molecular bacteria-fungi interactions: effects on environment, food, and medicine. Annu Rev Microbiol 67, 375-397.
(2013) Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem 14(18), 2439-2443.
(2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177.
(2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71.
(2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618.
(2012) Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydr Res 347(1), 95-98.
(2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7.
(2011) Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLoS One 6(1), e15731.
(2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53.
(2011) Impact of endofungal bacteria on infection biology, food safety, and drug development. PLoS Pathog 7(6), e1002096.
(2011) Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5(2), 252-261.
(2011) Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus. J Bacteriol 193(3), 783-784.
(2011) Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics 12, 210.
(2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287.
(2011) Genomics-inspired discovery of natural products. Curr Opin Chem Biol 15(1), 22-31.
(2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107.
(2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40), 13966-13968.
(2010) An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49(41), 7476-7480.
(2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013.
(2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986.
(2009) Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17(12), 570-576.
(2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30), 9306-9312.