Christian Hertweck

Prof. Dr. Christian Hertweck

Phone: +49 3641 532-1101 Email: christian.hertweck@leibniz-hki.de Website: www.leibniz-hki.de/de/biomolekulare-chemie.html

Projects

Current Projects

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Chemoenzymatic synthesis and derivatization of natural products
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On-line modification of processes in multimodular protein systems
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Natural Products from underexplored bacteria
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Compounds from neglected bacteria and target analysis
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Investigation of new photochemical reactions
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Investigations of Biosynthesis of Secondary Metabolites from Anaerobic Bacteria
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Former Projects

Genome mining of Gram-positive bacteria for secondary metabolites
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Molecular basis of bacterial-mushroom interactions
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The genome of the endofungal bacterium Burkholderia rhizoxinica
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Biochemical characterisation of bacterial terpene cyclases
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Genomics-Driven Discovery of Secondary Metabolites from Burkholderia spp. that Interact with Fungi
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Genomics-based search for natural products in neglected bacteria
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Publications

Ding L, Goerls H, Dornblut K, Lin W, Maier A, Fiebig HH, Hertweck C (2015) Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte. J Nat Prod , Details PubMed

Graupner K, Lackner G, Hertweck C (2015) Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announc 3(2), Details PubMed

Heine D, Sundaram S, Bretschneider T, Hertweck C (2015) Twofold polyketide branching by a stereoselective enzymatic Michael addition. Chem Commun (Camb) 51(48), 9872-9875. Details PubMed

Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J (2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), Details PubMed

Horn F, Üzüm Z, Möbius N, Guthke R, Linde J, Hertweck C (2015) Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417. Genome Announc 3(1), Details PubMed

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Mol Microbiol 96(1), 148-162. Details PubMed

Sundaram S, Heine D, Hertweck C (2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nat Chem Biol 11(12), 949-951. Details PubMed

Uzum Z, Silipo A, Lackner G, De Felice A, Molinaro A, Hertweck C (2015) Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae. Chembiochem 16(3), 387-392. Details PubMed

Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53(49), 13409-13413. Details PubMed

Heine D, Bretschneider T, Sundaram S, Hertweck C (2014) Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles. Angew Chem Int Ed Engl 53(43), 11645-11649. Details PubMed

Moebius N, Üzüm Z, Dijksterhuis J, Lackner G, Hertweck C (2014) Active invasion of bacteria into living fungal cells. Elife 3, e03007. Details PubMed

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed

Busch B, Ueberschaar N, Behnken S, Sugimoto Y, Werneburg M, Traitcheva N, He J, Hertweck C (2013) Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl 52(20), 5285-5289. Details PubMed

König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. Details PubMed

Nützmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA (2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109. Details PubMed

Scherlach K, Graupner K, Hertweck C (2013) Molecular bacteria-fungi interactions: effects on environment, food, and medicine. Annu Rev Microbiol 67, 375-397. Details PubMed

Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C (2013) Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem 14(18), 2439-2443. Details PubMed

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C (2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177. Details PubMed

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Scherlach K, Busch B, Lackner G, Paszkowski U, Hertweck C (2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618. Details PubMed

Silipo A, Leone MR, Lanzetta R, Parrilli M, Lackner G, Busch B, Hertweck C, Molinaro A (2012) Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydr Res 347(1), 95-98. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Gee JE, Glass MB, Lackner G, Helsel LO, Daneshvar M, Hollis DG, Jordan J, Morey R, Steigerwalt A, Hertweck C (2011) Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLoS One 6(1), e15731. Details PubMed

Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53. Details PubMed

Lackner G, Hertweck C (2011) Impact of endofungal bacteria on infection biology, food safety, and drug development. PLoS Pathog 7(6), e1002096. Details PubMed

Lackner G, Moebius N, Hertweck C (2011) Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5(2), 252-261. Details PubMed

Lackner G, Moebius N, Partida-Martinez L, Hertweck C (2011) Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus. J Bacteriol 193(3), 783-784. Details PubMed

Lackner G, Moebius N, Partida-Martinez LP, Boland S, Hertweck C (2011) Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics 12, 210. Details PubMed

Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J, Hertweck C, Strauss J, Brakhage AA (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287. Details PubMed

Winter JM, Behnken S, Hertweck C (2011) Genomics-inspired discovery of natural products. Curr Opin Chem Biol 15(1), 22-31. Details PubMed

Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Müller FM (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107. Details PubMed

Ishida K, Lincke T, Behnken S, Hertweck C (2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40), 13966-13968. Details PubMed

Leone MR, Lackner G, Silipo A, Lanzetta R, Molinaro A, Hertweck C (2010) An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49(41), 7476-7480. Details PubMed

Lincke T, Behnken S, Ishida K, Roth M, Hertweck C (2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013. Details PubMed

Lackner G, Möbius N, Scherlach K, Partida-Martinez LP, Winkler R, Schmitt I, Hertweck C (2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986. Details PubMed

Lackner G, Partida-Martinez LP, Hertweck C (2009) Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17(12), 570-576. Details PubMed

Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C (2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30), 9306-9312. Details PubMed

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