Christine Skerka

Prof. Dr. Christine Skerka

Phone: +49 3641 532-1164 Email: christine.skerka@leibniz-hki.de Website: www.leibniz-hki.de/de/infektionsbiologie.html

Projects

Current Projects

Characterisation of human complement regulators to Plasmodium falciparum
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N. N. 4
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The contribution of spore surface proteins of Lichtheimia corymbifera during infection of the host cells
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Former Projects

The role of CFHR proteins in human autoimmune diseases
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Characterization of the immediate early response of human dendritic cells to Candida albicans
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Complement evasion of human pathogenic microorganisms
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Role of human regulatory proteins of the complement system in health and disease
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Functional characterization of the soluble complement receptor type II (CR2/CD21) in infection
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Interaction of complement proteins and acute phase proteins in inflammatory processes
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Publications

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4. Details PubMed

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol , Details PubMed

Luo S, Hipler UC, Münzberg C, Skerka C, Zipfel PF (2015) Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical Candida albicans isolates. PLoS One 10(2), e0113192. Details PubMed

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Córdoba SR, Noris M, Pickering M, Smith R (2015) The role of complement in C3 glomerulopathy. Mol Immunol 67(1), 21-30. Details PubMed

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155. Details PubMed

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed

Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C (2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLoS One 8(11), e78617. Details PubMed

Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC (2013) Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24(1), 53-65. Details PubMed

Luo S, Hoffmann R, Skerka C, Zipfel PF (2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. J Infect Dis 207(4), 594-603. Details PubMed

Luo S, Skerka C, Kurzai O, Zipfel PF (2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169. Details PubMed

Koch TK, Reuter M, Barthel D, Böhm S, van den Elsen J, Kraiczy P, Zipfel PF, Skerka C (2012) Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. PLoS One 7(10), e47638. Details PubMed

Chen Q, Müller D, Rudolph B, Hartmann A, Kuwertz-Bröking E, Wu K, Kirschfink M, Skerka C, Zipfel PF (2011) Combined C3b and factor B autoantibodies and MPGN type II. N Engl J Med 365(24), 2340-2342. Details PubMed

Gropp K, Weber N, Reuter M, Micklisch S, Kopka I, Hallström T, Skerka C (2011) β₂-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator. Blood 118(10), 2774-2783. Details PubMed

Luo S, Blom AM, Rupp S, Hipler UC, Hube B, Skerka C, Zipfel PF (2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed

Zipfel PF, Skerka C, Kupka D, Luo S (2011) Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol 301(5), 423-430. Details PubMed

Fritsche LG, Lauer N, Hartmann A, Stippa S, Keilhauer CN, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Weber BH, Skerka C (2010) An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet 19(23), 4694-4704. Details PubMed

Luo S, Hartmann A, Dahse HM, Skerka C, Zipfel PF (2010) Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3. J Immunol 185(4), 2164-2173. Details PubMed

Heinen S, Hartmann A, Lauer N, Wiehl U, Dahse HM, Schirmer S, Gropp K, Enghardt T, Wallich R, Hälbich S, Mihlan M, Schlötzer-Schrehardt U, Zipfel PF, Skerka C (2009) Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation. Blood 114(12), 2439-2447. Details PubMed

Mihlan M, Stippa S, Józsi M, Zipfel PF (2009) Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H. Cell Death Differ 16(12), 1630-1640. Details PubMed

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