Alternative energy in the fungal cell
Out now: New paper in Nature Communications by Christine Dunker and colleagues
June 24, 2021
Until now, almost all studies suggested that the formation of hyphae is one of the most important virulence factors of the yeast Candida albicans. Ilse Jacobsen from Leibniz-HKI and her team have now shown for the first time that a mutant form of the fungus that does not form hyphae can also cause lethal systemic infections. The researchers report their findings in Nature Communications.
Dunker C, Polke M, Schulze-Richter B, Schubert K, Rudolphi S, Greßler AE, Pawlik T, Prada Salcedo JP, Niemiec MJ, Slesiona-Künzel S, Swidergall M, Martin R, Dandekar T, Jacobsen ID (2021) Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain. Nature Communications doi.org/10.1038/s41467-021-24095-8