Biosynthesis of basidiomycete polyenes
Various basidiomycetes produce polyene pigments, for which ecological functions have been assumed or shown. This project aims at characterizing polyene polyketide synthase genes and enzymes of selected basidiomycetes. Further, polyenes will be analyzed chemically and tested for their biological activity. The objective is a more profound understanding of fungal polyketide synthases and their products, and how structural features impact bioactivities. Methodologically, this project emphasizes chemical analysis, yet strongly interfaces with biochemistry, mycology, and molecular biology.
(2019) Production Options for Psilocybin: Making of the Magic. Chemistry 25(4), 897-903.
(2019) Injury-Triggered Blueing Reactions of Psilocybe Angew Chem Int Ed Engl 59(4), 1450-1454.
(2018) Analysis of basidiomycete pigments in situ by Raman spectroscopy. J Biophotonics 11(6), e201700369.
(2017) Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product. J Nat Prod 80(10), 2835-2838.
Start of PhD
April 1, 2017