Post-translational modifications and pathogenicity of the human pathogenic fungus Aspergillus fumigatus
Aspergillus nidulans, as other filamentous fungi, was found capable to produce a vast range of secondary metabolites, such as penicillin and sterigmatocystin. Many secondary metabolites are important not only for their impact on industry but also for their clinical relevance. However, most of the gene clusters involved in their production remain silent under standard cultivation conditions. Therefore a major aim of our studies is to unveil under which conditions those secondary metabolite clusters are activated.
Recent studies showed that chromatin remodelling is important for regulating secondary metabolite biosynthesis gene clusters. In our laboratories it had been found that SAGA/ADA, a histone acetyltransferase complex, is mediating the response of the fungus A. nidulans to the bacterium Streptomyces rapamycinicus and thereby is activating the biosynthesis of secondary metabolites.
In this study we are going to further investigate the role of SAGA/ADA in the activation of the cluster. And furthermore explore the direct impact of modifications on histones on the transcription of secondary metabolite gene clusters.
(2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. Elife 7,
(2016) Regulation and Role of Fungal Secondary Metabolites. Annu Rev Genet 50, 371-392.
(2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. Front Microbiol 6, 299.
(2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109.
Start of PhD
March 1, 2012
December 2, 2016