The entrainment of the circadian clock by light-dark and temperature cycles: Functional analysis of components of involved signaling pathways
CPF is a large gene family that includes photolyases (PLs) and cryptochromes (CRYs). PLs repair DNA damage while CRYs usually act as photoreceptors regulating a variety of biological processes. CRY-DASH (Cryptochrome-Drosophila, Arabidopsis, Synechocystis, Homo) is a subclade of CRYs and is discussed as an intermediate form between CRYs and PLs. It has been shown that CRY-DASHs are more similar to PLs structurally and retain repair activity. Though previous studies indicated that CRY-DASHs have signaling roles and some are under the control of circadian clock, little is known about the underlying mechanism.
In the green alga Chlamydomonas reinhardtii, a plant CRY and an animal-like CRY (aCRY) as well as two CRY-DASH-like proteins have been found based on the genome sequence. The focus of this work will be on the functional analysis of one of the CRY-DASH proteins.
Start of PhD
August 16, 2012
May 4, 2017