Phosphatidylinositol (PI) signaling in basidiomycete S. commune
The first study of phosphatidylinositol (PI) signaling in a basidiomycetous fungus Schizophyllum commune referred to inositol monophosphatase (IMPase), the second messenger in the PI Pathway which plays a role in the synthesis of inositol from inositol monophosphate. The imp has been found to be regulated in a Ras-dependent manner implying cross-talk during sexual development.
On the other hand, inositol depletion by Lithium chloride affects wildtype and a constitutively active Ras mutant, resulting: growth rate reduction, hyperbranching, and short cell lengths in both strains. In the wild type, a compensatory effect was observed with upregulation of imp prior to inositol depletion.
Furthermore, the modulation of imp in response to nitrogen starvation and knock-out of imp by homologous recombination will be demonstrated to know the functional analysis of inositol monophosphatase and to comprehend the feature of PI Signaling in S. commune.
(2019) Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune. Adv Biol Regul 72, 78-88.
Start of PhD
May 1, 2013
May 7, 2019