Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats.

Recknagel P, Gonnert FA, Halilbasic E, Gajda M, Jbeily N, Lupp A, Rubio I, Claus RA, Kortgen A, Trauner M, Singer M, Bauer M (2013) Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int 33(2), 283-293. PubMed

ILRS Authors

Ralf A. Claus Nayla Jbeily

Abstract
Many of the concepts describing molecular mechanisms of sepsis-induced liver failure are derived from endotoxin models. However, the biological significance of such models is questionable as the complexity of clinical sepsis and associated organ failure is only partially replicated.
Identifier

doi: 10.1111/liv.12012 PMID: 23146068

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