Total synthesis and functional analysis of microbial signalling molecules.

Leichnitz D, Raguž L, Beemelmanns C (2017) Total synthesis and functional analysis of microbial signalling molecules. Chem Soc Rev 46(20), 6330-6344. PubMed

ILRS Authors

Daniel Leichnitz Luka Raguz

Projects

Exploitation and total synthesis of new microbial sphingolipid-type signaling molecules
Details

Modular synthetic approaches towards natural sphingoid base-type signaling molecules
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Abstract

Communication is essential for all domains of life. Bacteria use a plethora of small molecules to sense and orchestrate intra- and interspecies communication. Within this review, we will discuss different groups of signalling molecules, including autoinducers, virulence factors and morphogenic substances. On selected examples, we will shortly discuss their ecological roles and biosynthetic proposals. The major part of this review will focus on a systematic overview of the different synthetic methods applied towards the synthesis of signalling molecules and derivatives thereof. The described examples highlight the importance of organic synthetic method development and diversity-oriented total syntheses for structure verification, structure-function analysis and target identification.

Identifier

doi: 10.1039/c6cs00665e PMID: 28902198

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