Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99.

Rak Lee S, Schalk F, Schwitalla JW, Benndorf R, Vollmers J, Kaster AK, de Beer ZW, Park M, Ahn MJ, Jung WH, Beemelmanns C, Kim KH (2020) Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99. J Nat Prod , PubMed

ILRS Authors

René Benndorf Jan Schwitalla Felix Schalk

Projects

Investigation of secondary metabolites from insect-associated microbes and their contribution to insect homeostasis and defense
Details

Metabolomic and transcriptomic analysis of the defensive role of Actinobacteria within the fungus-growing termite system
Details

Functional and genomic analysis of bacterial and fungal natural products derived from the fungus-growing termite
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Abstract

Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

Identifier

doi: 10.1021/acs.jnatprod.0c00676 PMID: 32946237

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