Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99.
(2020) Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99. J Nat Prod ,
Investigation of secondary metabolites from insect-associated microbes and their contribution to insect homeostasis and defense
Metabolomic and transcriptomic analysis of the defensive role of Actinobacteria within the fungus-growing termite system
Functional and genomic analysis of bacterial and fungal natural products derived from the fungus-growing termite
Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.
doi: 10.1021/acs.jnatprod.0c00676 PMID: 32946237