Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus.

König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. PubMed

ILRS Authors

Christian Hertweck Axel A. Brakhage Fabian Horn

Abstract
Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors.
Identifier

doi: 10.1002/cbic.201300070 PMID: 23649940

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