Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways.

Truta-Feles K, Lagadari M, Lehmann K, Berod L, Cubillos S, Piehler S, Herouy Y, Barz D, Kamradt T, Maghazachi A, Norgauer J (2010) Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways. Br J Pharmacol 161(6), 1291-1300. PubMed

ILRS Authors

Krisztina Truta-Feles

Projects

Function of phosphatidylinositol-3-kinase-gamma and SH2-containing inositol-5-phosphatase-1 in innate immunity
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Abstract

The biogenic amine, histamine plays a pathophysiological regulatory role in cellular processes of a variety of immune cells. This work analyses the actions of histamine on γδ-T lymphocytes, isolated from human peripheral blood, which are critically involved in immunological surveillance of tumours.

Identifier

doi: 10.1111/j.1476-5381.2010.00639.x PMID: 20977468

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