Bernhard Hube

Prof. Dr. Bernhard Hube

Phone: +49 3641 532-1400 Email: bernhard.hube@leibniz-hki.de

Projects

Current Projects

The role of filamentation in the pathogenesis of candidiasis
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Stepwise virulence regulation in Candida albicans
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Dissection of the Candida albicans lipase gene family and its role in commensalism and pathogenicity
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Elucidating the role of Candida albicans Ece1 peptides
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Antifungal Resistance: From Surveillance to Treatment
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How adaptaion of Candida albicans to inflammatory mediators impacts immune recognition and pathogenesis
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Former Projects

Intracellular survival of Candida glabrata in phagocytes
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Candida albicans – The pathway to epithelial damage
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Ceramide formation in host response to bacterial and fungal infection and development of organ failure
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Identification and characterization of infection-associated genes in Candida albicans
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The role of micronutrients during fungal infections
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Publications

Gerwien F, Safyan A, Wisgott S, Hille F, Kaemmer P, Linde J, Brunke S, Kasper L, Hube B (2016) A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts. MBio 7(5), Details PubMed

Höfs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54(3), 149-169. Details PubMed

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68. Details PubMed

Brunke S, Seider K, Richter ME, Bremer-Streck S, Ramachandra S, Kiehntopf M, Brock M, Hube B (2014) Histidine degradation via an aminotransferase increases the nutritional flexibility of Candida glabrata. Eukaryot Cell 13(6), 758-765. Details PubMed

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B (2014) Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One 9(5), e96015. Details PubMed

Ramachandra S, Linde J, Brock M, Guthke R, Hube B, Brunke S (2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PLoS One 9(3), e92734. Details PubMed

Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, Schwarzmüller T, Barz D, Rupp S, Kuchler K, Hube B (2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13(1), 170-183. Details PubMed

Mayer FL, Wilson D, Hube B (2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. PLoS One 8(3), e60417. Details PubMed

Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLoS One 7(12), e52850. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Luo S, Blom AM, Rupp S, Hipler UC, Hube B, Skerka C, Zipfel PF (2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed

Müller S, Fleck CB, Wilson D, Hummert C, Hube B, Brock M (2011) Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases. Environ Microbiol 13(6), 1534-1548. Details PubMed

Hummert S, Hummert C, Schröter A, Hube B, Schuster S (2010) Game theoretical modelling of survival strategies of Candida albicans inside macrophages. J Theor Biol 264(2), 312-318. Details PubMed

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