Marie Goldmann

Marie Goldmann (née Röcker)

Phone: +49 3641 532-1506 Email: marie.roecker@leibniz-hki.de

Identification of immunogenic components of Aspergillus fumigatus for vaccine development

Aspergillus fumigatus is the most important air-borne fungal pathogen. In recent years, it became evident that certain unknown components of A. fumigatus apparently lead to protection against invasive aspergillosis in a mouse infection model. Until now, it remains to be shown whether the protection is due to a B cell response or rather T cell response.
Furthermore, the components of A. fumigatus triggering this response have not been identified.

The proposed project will investigate, which morphotypes (spore, mycelium) promote an immune response and which protein antigens contribute to this host reaction. The immunological properties of selected protein antigens will be further investigated in murine models of Invasive Aspergillosis (8-cells, T-cells). In collaboration with the Charité (Berlin)
the T-cell response against IA of Cystic Fibrosis patients will be characterized.

Publications

Blango MG, Pschibul A, Rivieccio F, Krüger T, Rafiq M, Jia L, Zheng T, Goldmann M, Voltersen V, LiJ, Panagiotou P, Kniemeyer O, Brakhage AA (2020) The dynamic surface proteomes of allergenic fungal conidia J Proteome Res 19(5), 2092-2104. Details Open Access

Supervisor

Axel A. Brakhage

Co-Supervisors

Peter F. Zipfel Olaf Kniemeyer

Start of PhD

June 1, 2015

Doctoral Disputation

March 3, 2020

Go back