Reinhard Guthke

PD Dr. Reinhard Guthke

Phone: +49 3641 532-1083 Email: reinhard.guthke@leibniz-hki.de Website: www.leibniz-hki.de/de/systembiologie-und-bioinformatik.ht

Projects

Former Projects

Integration of transcriptome and proteome data from human-pathogenic fungi
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Automated analysis of dynamic properties in biological systems from image data
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Prediction of gene regulatory networks involved in the differentiation, secondary metabolism and cross talk of Aspergillus nidulans
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Bioinformatic investigation and prediction of gene regulatory elements in pathogenic fungi
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Optimization of the influenza neuraminidase inhibitor therapy by use of secondary bacterial infections
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Integrated genome-wide data analysis by ensemble learning methods to understand infection processes
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Analysis and interpretation of variance in gene expression data
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Publications

Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J (2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), Details PubMed

Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Brakhage AA, Valiante V (2015) Draft Genome Sequence of the Fungus Penicillium brasilianum MG11. Genome Announc 3(5), Details PubMed

Horn F, Üzüm Z, Möbius N, Guthke R, Linde J, Hertweck C (2015) Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417. Genome Announc 3(1), Details PubMed

Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O (2015) Defining the transcriptomic landscape of Candida glabrata by RNA-Seq. Nucleic Acids Res 43(3), 1392-1406. Details PubMed

Priebe S, Kreisel C, Horn F, Guthke R, Linde J (2015) FungiFun2: a comprehensive online resource for systematic analysis of gene lists from fungal species. Bioinformatics 31(3), 445-446. Details PubMed

Horn F, Rittweger M, Taubert J, Lysenko A, Rawlings C, Guthke R (2014) Interactive exploration of integrated biological datasets using context-sensitive workflows. Front Genet 5, 21. Details PubMed

Horn F, Schroeckh V, Netzker T, Guthke R, Brakhage AA, Linde J (2014) Draft Genome Sequence of Streptomyces iranensis. Genome Announc 2(4), Details PubMed

Manchanda H, Seidel N, Krumbholz A, Sauerbrei A, Schmidtke M, Guthke R (2014) Within-host influenza dynamics: a small-scale mathematical modeling approach. Biosystems 118, 51-59. Details PubMed

Ramachandra S, Linde J, Brock M, Guthke R, Hube B, Brunke S (2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PLoS One 9(3), e92734. Details PubMed

Müller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC Genomics 13, 519. Details PubMed

Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R (2011) On the way toward systems biology of Aspergillus fumigatus infection. Int J Med Microbiol 301(5), 453-459. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One 6(5), e19591. Details PubMed

Priebe S, Linde J, Albrecht D, Guthke R, Brakhage AA (2011) FungiFun: a web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol 48(4), 353-358. Details PubMed

Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Müller FM (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107. Details PubMed

Teutschbein J, Albrecht D, Pötsch M, Guthke R, Aimanianda V, Clavaud C, Latgé JP, Brakhage AA, Kniemeyer O (2010) Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res 9(7), 3427-3442. Details PubMed

Vödisch M, Albrecht D, Lessing F, Schmidt AD, Winkler R, Guthke R, Brakhage AA, Kniemeyer O (2009) Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics 9(5), 1407-1415. Details PubMed

Albrecht D, Kniemeyer O, Brakhage AA, Guthke R (2008) Normalisation of 2D DIGE data - on the way to a standard operating procedure. BIRD08 Schriftenreihe Informatik 26, 55-64. Details

Huber R, Hummert C, Gausmann U, Pohlers D, Koczan D, Guthke R, Kinne RW (2008) Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther 10(4), R98. Details PubMed

Guthke R, Kniemeyer O, Albrecht D, Brakhage AA, Moeller U (2007) Discovery of gene regulatory networks in Aspergillus fumigatus. Lect Notes Bioinf 4366, 22-41. Details

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